Psychological impact of Mayer-Rokitansky-Küster-Hauser syndrome: Coping mechanisms, emotional challenges, and mental health support

Abstract

Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a rare congenital condition characterized by the complete or partial absence of the uterus and the upper two-thirds of the vagina in individuals who have a typical female karyotype (46,XX) and normal ovarian function. This case report presents a 19-year-old female diagnosed with MRKH syndrome type 2, associated with renal anomalies such as ectopic fused kidneys. The patient exhibited significant psychological distress, including depression, anxiety, body image issues, and a history of suicide attempt. Management involved a multidisciplinary approach encompassing anatomical correction through prior vaginoplasty, psychiatric intervention with pharmacotherapy and cognitive-behavioral therapy and counseling regarding reproductive options like surrogacy and adoption. This report highlights the importance of early diagnosis, psychological support, and comprehensive care in improving the quality of life for individuals affected by MRKH syndrome.